Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum.
نویسندگان
چکیده
Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-2beta,12alpha,16alpha,23alpha-tetrahydroxyoleanane-28(13)-lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.
منابع مشابه
Platyconic acid A, a genuine triterpenoid saponin from the roots of Platycodon grandiflorum.
A genuine triterpenoid saponin, platyconic acid A (1) was isolated from the roots extract of Platycodon grandiflorum, together with five known saponins: deapioplatycoside E (2), platycoside E (3), platycodin D(3) (4), platycodin D(2) (5) and platycodin D (6). The structure of 1 was determined on the basis of spectral analysis and chemical evidence.
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The extracts and pure saponins from the roots of Platycodon grandiflorum (PG) are reported to have a wide range of health benefits. Platycosides (saponins) from the roots of PG are characterized by a structure containing a triterpenoid aglycone and two sugar chains. Saponins are of commercial significance, and their applications are increasing with increasing evidence of their health benefits. ...
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ورودعنوان ژورنال:
- Molecules
دوره 12 4 شماره
صفحات -
تاریخ انتشار 2007